Tuesday, September 4, 2007

Author Calls his own CNS Spectrums Article “Ridiculous, Inaccurate, Simplistic”

C. Lindsay DeVane, a Professor of Psychiatry and an author of an ACCME-accredited article published in the journal CNS Spectrums has termed his article a “piece of commercial crap,” and said he had not read the final version before it was published, according to an e-mail he sent to this writer (read his e-mail here).

DeVane, who is Professor of Psychiatry and Behavioral Sciences and Vice Chair for Research at the Medical University of South Carolina, is one of three authors listed for an “Expert Roundtable Supplement” published with the May 2007 issue of CNS Spectrums. The supplement was accredited and produced by i3 CME, a medical education company owned by Ingenix, and was funded by Bristol-Myers Squibb.

Responding in an e-mail to questions I had about the accuracy of the article (read this e-mail here), Dr. DeVane said that he had originally been approached by Dr. Charles Nemeroff to participate in a videotaped discussion to be held at a psychiatric meeting in Hawaii. The discussion was to be funded by Bristol-Myers Squibb, which recently released the antidepressant patch, EMSAM. DeVane initially declined Dr. Nemeroff’s invitation, saying that he did not want to participate in a “circus debate for the sake of selling CME time.” However, he eventually changed his mind and participated in a discussion of antidepressant drug-drug interactions with Nemeroff and Sheldon Preskorn, another high-profile academician who often consults and speaks for drug companies.

After the broadcast, the CME company, i3 CME, presented DeVane with an article based on the discussion, apparently ghost-written by a medical writer hired by the company. DeVane called this a “ridicuous text… parts of it were inaccurate, simplistic, and [contained] over-generalizations.” It is not clear whether DeVane insisted that editorial changes be made. He had not read the final version, and advised that the article be ignored “for purposes of interpreting my research and views.”

The controversy involves a seemingly arcane topic in psychopharmacology, the issue of how drugs interact with other drugs in the bloodstream. In an earlier article in a different journal, published without pharmaceutical funding, Dr. DeVane had argued that these drug-drug interactions were rarely significant when prescribing antidepressants. According to DeVane’s e-mail, that article “represents my summary of the field and opinions.”

The CNS Spectrums article, however, claims that these interactions are often significant when certain antidepressants are used. The article also points out that EMSAM, the drug made by the article’s sponsor, has the advantage of not sharing these drug interaction liabilities. If DeVane’s earlier statements had been used as the basis for the article, then EMSAM could not have been claimed to have this competitive advantage.

In response to inquiries about the discrepancies in DeVane’s earlier article and the newer article, CNS Spectrums and i3 CME did not comment on specifics, but denied any irregularities regarding the planning or writing of the article. According to their written statement, “the faculty [referring to Nemeroff, Preskorn, and DeVane] remains comfortable with the positions they have taken in this CME activity….”

File article under: Corruption in High Places

21 comments:

Anonymous said...
This comment has been removed by a blog administrator.
James La Rossa said...

4 September 2007

Daniel Carlat, MD
Editor-in-Chief
The Carlat Psychiatry Report
42 Pleasant Street
P.O. Box 626
Newburyport MA 01950

Dear Dr. Carlat:

I have read with great fascination your recent criticism of the educational credibility (or lack thereof) of industry-sponsored CME activities, most particularly, CNS Spectrums: "A Piece of Commercial C__p" (Tuesday, August 14, 2007). This was especially interesting in light of author Lindsey DeVane's blanket 10-count of the BMS-sponsored project, in which he, too, referred to the published article as "a piece of commercial crap."

As the original publisher of CNS Spectrums, which we started in 1997 and sold to the present publisher in 2003, I might be able to lend some insight into a specific part of the debate; that is—the relationship between publishers, industry, and the ACCME.

I first asked Charles Nemeroff to write a piece on psychotropic drug/drug interactions for CNS Spectrums 10 years ago, when the subject was more noteworthy than, perhaps, it is today. (Remember the CYP 450 debate...?) After the article was published in the journal, we were approached by a sponsoring company who asked if they could license the piece for their use WITHOUT ANY CHANGES TO THE MATERIAL. Nemeroff consented. We were paid for the license and, thus, paid the authors. Commercial interests aside, it was important to me (as a journalist and editor with many science-related bylines) to first have the article independently published. If the article was subsequently sponsored by industry, we were confident that it would pass scientific scrutiny and we would retain the most important qualification of any publisher: Third party credibility. Thus, it was highly critical that we monitored ourselves very carefully. There was never any question of whether the article needed CME accreditation to validate its independence.

Here's the rub: Publisher's have First Amendment rights to publish, virtually, anything they want. This luxury has given journals the ability to go directly to a given pharma company to produce sponsored, customized projects BEFORE publication—becoming, in effect, a private content supplier for industry.

Industry does not enjoy the publisher's First Amendment protection. Consequently, the medical-legal division of these companies have, universally, adopted the rules and regulations of the ACCME in order for sponsored material to pass FDA muster. Ironically, Pharma may not be solely at fault since the FDA has clearly endorsed ACCME-like standards. (See, attached, Final Guidance on Industry-Supported Scientific and Educational Activities. Federal Register; Vol. 62, No. 232. 64073-64092.)

What we are witnessing is that publishers of advertising-generated publications (in all fairness, you could have included me in that category once) bang the same drum over and over again for the simple reason that it is easy. So, it is not a stretch to believe that you are all sick and tired of this, which your blog seems to confirm. In truth, the CME business has become rotten to the core.

The authors of these industry-sponsored "projects" are not solely to blame. (Though you can blame the editors who should know better...) The galley proofs are thrown at them with such velocity that they have little time for review. The authors are no longer on their own timetable, but that of the sponsor and publisher.

One last thing for the record. DeVane's denial of responsibility for the CNS Spectrums debacle is not altogether fair. I am willing to bet dollars to doughnuts that Nemeroff never saw proofs of the article either. While it might be fashionable to throw barbs at the big-money speakers, guys like Nemeroff have made a significant contribution to the field.


Yours truly,


James M. La Rossa Jr.
Editorial Director & Publisher
MedWorks Media Global, LLC.

Philip Dawdy said...

great post and great work

Anonymous said...

有什么 有什么网址 有什么新闻 有什么博客 有什么论文 有什么图片 有什么音乐 有什么搜商 有什么帖客 天气预报

烟雨遥 said...

白癜风的临床表现是什么?

白癜风为皮损色素完全脱失,呈瓷白色斑,白斑大小形态不一,境界清楚,边缘有色素沉着增加,无自觉症状,暴晒后易出现红斑,甚至水泡,自觉有灼痛、炎症后,白斑可比原发范围大,皮损可发生于任何部位,但较常见于指背、腕、前臂、面颈、生殖器及其周围。白斑常对称或单侧分布,甚至如带状沿神经分布。头部白斑边缘无色素沉着区,或偶有白发而看不出白斑。有的白斑可自行消退,一些患者在夏季日晒后,白斑中心或边缘色素再生,但到冬季色素又可消退。部分患者可伴有粘膜色素减退以口唇多见,外生殖器次之,眼色素亦可受累,但一般不影响视力,这种粘膜白癜风不同于通常所说的粘膜白斑。

外阴白斑以往多主张手术切除,但术后复发率高。近年来通过对以往所谓外阴白斑进行长期随访,发现癌变率仅2%左右;即使已有上皮非典型增生者,也仅有一小部分可发展为原位癌或浸润癌。且实践证明,为控制局部瘙痒,或恢复外阴皮肤正常形态,药物治疗均能取得较为满意的效果。故目前大多主张采用非手术治疗,但治疗后仍应继续随访,特别对增生型营养不良而有溃破、硬结者更应提高警惕,以防发生癌变。
为了统一认识,1975年国际外阴病研究会决定取消“外阴白斑”病名,改称为“慢性外阴营养不良”(ChronicVuIVardystroph),并根据组织病理变化的不同,将其分为3种不同的类型。
外阴白斑是发生在外阴皮肤粘膜处的白色病变,以病变处皮肤增厚、粗糙、萎缩、弹性减退、皮色脱失为特征,常见于大阴唇或小阴唇内侧及阴蒂,严重时可延至阴道、会阴及肛门周围的一种慢性常见妇科疾病。

烟雨遥 said...

气相色谱仪
忧伤满杯
SEO
SEO博客
SEO优化排名
SEO博客
凌枫博客
SEO日志
龙翔
网络营销
ewgoogle
SEO社区

tonyparker said...

wow gold
cheap wow gold
wow guide
nba live
火箭队
google排名
buy wow gold
world of warcraft gold
runescape
google左侧排名
wow gold
runescape money
lotro
lotro gold
google排名服务
guild wars
guild wars gold
dofus
dofus kamas
world of warcraft gold
maple story
maple story mesos
maple story
maple story mesos

Anonymous said...

wow gold
wow gold
wow power leveling
wow power leveling
wow gold@@@@
World of Warcraft Gold
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow power leveling
wow powerleveling
wow powerleveling
wow powerleveling
rolex replica
wow powerleveling
wow powerleveling
wow powerleveling
wow powerleveling
wow powerleveling
wow powerleveling
wow powerleveling
wow powerleveling
replica rolex
powerleveling
powerleveling
powerleveling
powerleveling
power leveling
power leveling
powerleveling
powerleveling
power leveling
power leveling
power leveling
power leveling
power leveling
power leveling
power leveling
power leveling
rolex
wow gold
wow gold
Warcraft Gold
Warcraft Gold

中高年 転職
アルバイト 求人情報
ブライダル
転職
競馬
FX
ダイエット
お見合い
競馬 予想
新築マンション
新築マンション
コンタクトレンズ
婚約指輪
合宿免許
人材派遣
東京都 墓地
派遣会社
人材派遣
パチンコ 攻略
おなら

货架
OCR
OCR
手机词典
高速扫描
机票
灭蟑螂
蜗轮减速机
减速机
齿轮减速机
丝杆升降机
租房
租房
北京租房
北京租房
搬家公司
北京搬家
北京搬家公司
上海机票
上海机票
上海打折机票
上海打折机票
上海特价机票
上海特价机票
搬家公司
搬家公司
北京搬家公司
北京搬家公司

dgfghjghkg

Anonymous said...

wow gold
world of warcraft gold
gold wow
buy wow gold
cheap wow gold
guild wars gold
gw gold
cheap guild wars gold
buy guild wars gold
Maple Story Mesos
MapleStory Mesos
Maple Mesos
Maple Story Meso
cheap Maple Story Mesos
cheap MapleStory Mesos
guild wars money
buy Maple Story Mesos
cheap Maple Story Meso
cheap guild wars money
cheap gw money
gw money
buy Maple Meso
薬剤師求人
インプラント
レーシック
会社設立
seo
seo対策
power leveling
wow power leveling
runescape gold
runescape money
rs gold
runescape gp

Anonymous said...

wow gold
cheap wow gold
buy wow gold
world of warcraft gold
wow
world of warcraft
wow gold
WoW Warrior
WoW Hunter
WoW Rogue
WoW Paladin
WoW Shaman
WoW Priest
WoW Mage
WoW Druid
WoW Warlock
google排名
google左侧排名
google排名服务
百度推广
百度排名
机床
LED灯
电池
塑料
摄像机
电动车
包装设计
移民
甲醇
染料
体育博客
股票博客
游戏博客
魔兽博客
考试博客
logo design
website design
web design
商标设计

Anonymous said...

World Of Warcraft gold for cheap
wow power leveling,
wow gold,
wow gold,
wow power leveling,
wow power leveling,
world of warcraft power leveling,
wow power leveling,
cheap wow gold,
cheap wow gold,
maternity clothes,
wedding dresses,
jewelry store,
wow gold,
world of warcraft power leveling
World Of Warcraft gold,
ffxi gil,
wow account,
world of warcraft power leveling,
buy wow gold,
wow gold,
Cheap WoW Gold,
wow gold,
Cheap WoW Gold,
wow power leveling
world of warcraft gold,
wow gold,
evening gowns,
wedding gowns,
prom gowns,
bridal gowns,
oil purifier,
wedding dresses,
World Of Warcraft gold
wow gold,
wow gold,
wow gold,
wow gold,
wow power level,
wow power level,
wow power level,
wow power level,
wow gold,
wow gold,
wow gold,
wow po,
wow or,
wow po,
world of warcraft gold,
cheap world of warcraft gold,
warcraft gold,
world of warcraft gold,
cheap world of warcraft gold,
warcraft gold,buy cheap World Of Warcraft gold
Maple Story mesos,
MapleStory mesos,
ms mesos,
mesos,
SilkRoad Gold,
SRO Gold,
SilkRoad Online Gold,
eq2 plat,
eq2 gold,
eq2 Platinum,
EverQuest 2 Platinum,
EverQuest 2 gold,
EverQuest 2 plat,
lotro gold,
lotr gold,
Lord of the Rings online Gold,
wow powerleveling,
wow powerleveling,
wow powerleveling,
wow powerleveling,world of warcraft power leveling
ffxi gil,ffxi gil,ffxi gil,ffxi gil,final fantasy xi gil,final fantasy xi gil,final fantasy xi gil,final fantasy xi gil,world of warcraft gold,cheap world of warcraft gold,warcraft gold,world of warcraft gold,cheap world of warcraft gold,warcraft gold,guildwars gold,guildwars gold,guild wars gold,guild wars gold,lotro gold,lotro gold,lotr gold,lotr gold,maplestory mesos,maplestory mesos,maplestory mesos,maplestory mesos, maple story mesos,maple story mesos,maple story mesos,maple story mesos,
i3u6h7dt

ithaca said...

医師 募集
看護師 求人
治験
防犯カメラ
ウィークリーマンション
アトピー
人材紹介
転職
キャッシング
人材派遣
携帯電話
不動産担保ローン
介護
看護師
会社設立
キャッシング
特許事務所
カラコン
ウコン
自動車ガラス
ペット 求人
害虫駆除
美容学校
太陽光発電
横浜中華街
基礎化粧品
データ 復旧
葬儀 東京
バイアグラ
メル友
月経困難症
マンションリフォーム
住宅リフォーム
スカッシュ DVD
ダイビング
イメージコンサルタント
カラーコーディネーター
会社設立
SSL
就職ナビ
広告業界
アダルトグッズ
アンチエイジング 化粧品
アメリカ ビザ
マッスルトレーナー
ウォーキングシューズ
サウナスーツ
マンスリーマンション 東京
有料老人ホーム
永代供養
永代供養
永代供養
納骨堂 弁理士

Anonymous said...

World Of Warcraft gold for cheap
wow power leveling,
wow gold,
wow gold,
wow power leveling,
wow power leveling,
world of warcraft power leveling,
world of warcraft power leveling
wow power leveling,
cheap wow gold,
cheap wow gold,
buy wow gold,
wow gold,
Cheap WoW Gold,
wow gold,
Cheap WoW Gold,
world of warcraft gold,
wow gold,
world of warcraft gold,
wow gold,
wow gold,
wow gold,
wow gold,
wow gold,
wow gold,
wow gold
buy cheap World Of Warcraft gold r3o6h7qt

Anonymous said...

runescape runescape money runescape gold buy runescape money buy runescape gold runescape cheat runescape tip lotro lotro gold lotro golds buy lotro gold buy lotro golds lord of the rings online lord of the rings online gold lotro lotro gold lotro golds buy lotro gold buy lotro golds lord of the rings online lord of the rings online gold runescape runescape money runescape gold buy runescape money buy runescape gold runescape cheats runescape tips guild wars guild wars gold dofus dofus kamas lotro lotro gold guild wars gold guild wars gold guild wars gold maple story maple story mesos maplestory mesos maple story maple story mesos maplestory mesos maple story maple story mesos maplestory mesos runescape runescape money runescape gold buy runescape money buy runescape gold www.runescape.com runescape.com runescape items dofus dofus kamas dofus kamas guild wars guild wars guild wars runescape runescape money runescape money runescape gold buy runescape money buy runescape gold runescape.com runescape items

Anonymous said...

wow gold cheap wow gold buy wow gold world of warcraft gold wow world of warcraft wow gold WoW Warrior WoW Hunter WoW Rogue WoW Paladin WoW Shaman WoW Priest WoW Mage WoW Druid WoW Warlock power leveling powerleveling wow power leveling wow powerleveling wow guides wow tips google排名 google左侧排名 google排名服务 百度推广 百度排名 网站推广 商业吧 机床 LED灯 电池 塑料 摄像机 移民 甲醇 染料 福州热线 体育博客 股票博客 游戏博客 魔兽博客 考试博客 汽车博客 房产博客 电脑博客 powerlin518 logo design website design web design 商标设计

titi said...

runescape money runescape gold runescape gold buy runescape gold runescape money runescape gold wow power leveling wow powerleveling Warcraft Power Leveling Warcraft PowerLeveling buy runescape gold buy runescape money runescape itemsrunescape accounts runescape gp dofus kamas buy dofus kamas Guild Wars Gold buy Guild Wars Gold lotro gold buy lotro gold lotro gold buy lotro gold lotro gold buy lotro gold runescape money runescape power leveling runescape money runescape gold dofus kamas cheap runescape money cheap runescape gold Hellgate Palladium Hellgate London Palladium Hellgate money Tabula Rasa gold tabula rasa money Tabula Rasa Credit Tabula Rasa Credits Hellgate gold Hellgate London gold wow power leveling wow powerleveling Warcraft PowerLeveling Warcraft Power Leveling World of Warcraft PowerLeveling World of Warcraft Power Leveling runescape power leveling runescape powerleveling eve isk eve online isk eve isk eve online isk tibia gold Fiesta Silver Fiesta Gold SilkRoad Gold buy SilkRoad Gold runescape accounts buy runescape accounts rs2 accounts buy rs2 accounts runescape power leveling rs2 power leveling FFXI Gil buy FFXI Gil buy dofus kamas buy dofus kamas dofus kamas
runescape accounts
buy runescape accounts
rs2 accounts
buy rs2 accounts
runescape power leveling
rs2 power leveling

waou said...

Yahoo!に強いSEO対策
Yahooに強いSEO対策
ホームページ制作の料金比較
リフォームの見積り
インプラント治療
電話占いで恋愛相談
リアルマネートレードでオンラインでライバルに勝つ
キャッシング比較でお得にお金を借りる
キャッシング比較サイトでお得なキャッシング情報
カードローン比較で最適なカード作り
FXオンライン取引で投資
保育士求人サイトで保育園に転職する
医学部受験なら医学部予備校に
うつ病の治療方法があった
金融転職なら金融セミナー
Serviced Apartments Tokyo
クレジット枠を現金化する
リアルマネートレードでリネージュ2でライバルに差をつける
真珠のアクセサリーでセレブになる
中古パソコンでビジネスシーンを乗り切る
医療機器なら医療マーケティングのヒューマ
Youtubeのアニメを見る
Youtubeで映画を見る
Youtubeでドラマを見る

wangfei.wf2008 said...

版主支持你 蛋糕 eq2 gold 肾炎 搬家 北京搬家 咖啡机 optical filter bandpass filter dichroic filter 北京翻译公司 电子白板 集团电话 门禁系统 门禁 光盘刻录 北京机票 美国机票 欧洲机票 国际机票 机票代理 工业设计 门禁 机柜 光盘刻录 钻石 激光打标 空调移机 婚庆公司 北京婚庆 美国留学 空调移机 空调维修 空调安装 空调移机 北京空调移机 厨房设备 glass mosaic handmade tiles 电路板 线路板 月嫂 平衡机 宝石 油烟净化 哮喘 结缔组织病 口腔溃疡 前列腺炎 前列腺增生 前列腺癌 早泄 阳痿 血尿 注册会计师 肩周炎 空调维修 模具 茶具 月嫂 咳嗽 哮喘 英语翻译 音响 厨房用具 酒店用品 厨房设备 咖啡机 机票 国际机票 国内机票 搬家公司 北京搬家公司 搬家 搬家公司 北京搬家 北京搬家公司 婚纱 礼服 婚纱摄影 胶带 圣诞树 小本创业 小投资 条码打印机 证卡打印机 打印机 证卡机 标签打印机 吊牌打印机 投影机 投影仪 月嫂 育儿嫂 月嫂 育儿嫂 月嫂 育儿嫂 冷冻干燥机 溴化锂制冷机 塑钢门窗 滤光片 无缝管 生日礼物的选择 塑钢门窗厂 鸡眼 吸塑包装 注浆加固公司 电动车维修 电池修复

Anonymous said...

qcsglll
翻译公司
货架
卷帘门
电动门
自动门
卷帘门
道闸
车库门
伸缩门
锅炉安装
Oracle数据库容灾复制
Oracle容灾备份
Oracle备份恢复
车库门
自动车库门
防火卷帘门
阳光房

道闸
挡车器
伸缩门
电动伸缩门
货架
货架
货架
货架
日上
日上防盗门
北京铁艺

车库门
卷帘门
伸缩门
岗亭
岗亭
岗亭
岗亭
岗亭
岗亭
车库门
道闸
卷帘门
防火卷帘门
电动伸缩门
道闸
防火卷帘门
自动车库门
车库门
伸缩门
电动伸缩门
挡车器
电动伸缩门
伸缩门
卷帘门
车库门
道闸
挡车器



岗亭
道闸
伸缩门
自动门
车库门
岗亭
电动伸缩门
卷帘门
自动门
电动门
伸缩门
卷帘门
车库门
伸缩门
自动车库门
车库门
伸缩门

电动伸缩门
道闸
岗亭
自动车库门
电动伸缩门
岗亭
卷帘门
车库门
伸缩门
电动门
自动门


北京SEO
专业SEO
专业SEO
专业SEO

Anonymous said...

bgwldwzjzzxh!!
热门图库
热门图库精
六合彩
妇科

qweaq said...

wow gold
wow gold
wow gold
wow gold
wow power leveling
wow power leveling
wow power leveling
wow power leveling
World of Warcraft Gold
wow gold
wow power leveling
wow gold
wow gold
wow gold
wow power leveling
wow power leveling
Rolex Replica
rolex
Rolex Replica
rolex
Rolex
租房
租房
北京租房
北京租房
changyongkuivip